Resources
Content library
Application notes, webinars, key publications and news from ELDICO electron diffraction.
Application notes
AN10 · Pharma
Unlocking the crystal structures of marketed drugs
Febuxostat
A case study of febuxostat – a long-missing crystal structure solved from nanocrystals by electron diffraction.
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AN11 · Biomolecules
Biogenic crystal structure determination with 3D ED
Guanine
Guanine solved directly from crude biological material – spider integument, fish scales and scallop eyes.
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AN12 · Method
Electron diffraction
Nequinate
Structure determination directly from nanocrystalline powders – no need to grow large single crystals.
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AN13 · Pharma
Electron diffraction: advancing mechanical chemistry
Quininium aspirinate
MicroED characterises mechanochemical products – finding the crystal hiding in an amorphous drug–drug salt.
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AN14 · Pharma
Enhanced polymorph screening using electron diffraction
Aripiprazole
Solid-form identification and quantification – an Ardena & ELDICO case study on aripiprazole.
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AN15 · Pharma
Precision in powder analysis
Carvedilol
Electron diffraction for milled pharmaceuticals – detecting residual crystallinity that PXRD can miss.
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AN16 · Agro
3D ED analysis of agrochemical nanocrystals
Mesotrione
From spray-droplet crystallisation – a Syngenta & ELDICO case study on mesotrione.
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AN17 · Biomolecules
3D ED for biomolecules: Vitamin B2
Vitamin B2
Riboflavin solved from sub-micron needles – with dedicated-instrument data quality and absolute configuration.
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AN18 · Pharma
A new polymorphic form of Dapsone
Dapsone
Found with automated electron diffraction (microED) experiments on a commercial sample.
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AN19 · Pharma
3D ED and CSP: Derisking Drug Development
Ritonavir
Completing the ritonavir polymorph landscape – finding the form that had eluded structural characterisation.
Download the application noteWebinars & on-demand
On demand · 2026
Pharmaceutical applications of MicroED – on-demand webinar
How micro-electron diffraction resolves polymorphs, salts, cocrystals and absolute configuration for pharmaceutical R&D. Watch on demand.
Watch / registerOn demand · Part 24
Deciphering the topology of less-ordered materials using solid-state NMR and electron diffraction
Dr. Brijith Thomas (NYU Abu Dhabi) – combining ssNMR and electron diffraction to characterise low-crystallinity and disordered materials.
Watch / registerOn demand · Part 23
Shape-assisted self-assembled nanosheets studied with electron diffraction
Dr. Joseph Woods (ETH Zurich) and Prof. Bernhard Spingler (University of Zurich) – electron diffraction on self-assembled supramolecular nanosheets.
Watch / registerOn demand · Part 22
In the footsteps of Pasteur: finding conglomerates with electron diffraction
Dr. Ivo Rietveld (Rouen/Paris) – electron diffraction for detecting chiral conglomerates, a route to chiral resolution relevant to pharma.
Watch / registerOn demand · Part 21
Micro-electron diffraction of amorphous phases from mechanochemistry and the structural analysis of MOFs
Dr. Silvina Pagola (Old Dominion University) – electron diffraction screening of poorly crystalline and amorphous salts, with a formulation-stability angle.
Watch / registerOn demand · Part 20
3D electron diffraction of nanocrystalline reticular materials from mechanochemical synthesis
Danilo Marchetti (University of Parma / IIT Pisa) – 3D electron diffraction of nanocrystalline MOFs and COFs obtained by mechanochemistry.
Watch / registerOn demand · Part 19
The role of electron diffraction in nanoparticle growth mechanism and crystal structure
Dr. Arnaud Magrez (EPFL) – electron diffraction applied to nanoparticle growth mechanisms and structure.
Watch / registerVideos
Talks, explainers and results – straight from the ELDICO channel.
Key publications
Nature Communications 14, 4725 · 2023
Saddles as rotational locks within shape-assisted self-assembled nanosheets
J. F. Woods, L. Gallego, A. Maisch, et al.
Read the paper →Communications Chemistry 8, 404 · 2025
Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution
L. Iuzzolino, A. W. Kelly, M. T. Chaudhry, C. Jandl, D. Stam, A. Y. Lee
Read the paper →Acta Cryst. E79, 410 · 2023
Electron crystallography and dedicated electron-diffraction instrumentation
P. Simoncic, E. Romeijn, E. Hovestreydt, G. Steinfeld, G. Santiso-Quinones, J. Merkelbach
Read the paper →Symmetry 15, 983 · 2023
Absolute Structure Determination of Chiral Zinc Tartrate MOFs by 3D Electron Diffraction
C. Jandl, G. Steinfeld, K. Li, P. K. C. Pang, C. L. Choi, C. Wang, P. Simoncic, I. D. Williams
Read the paper →Imaging & Microscopy 3, 31 · 2023
Crystal mapping by continuous rotation electron diffraction
J. Merkelbach, D. Stam, C. Jandl, V. Kushwah, A. Paudel, P. Simoncic
Read the paper →Drug Discovery Today 27(2), 371-373 · 2022
Electron diffraction: Accelerating drug development
E. Hovestreydt
Read the paper →Cryst. Growth Des. 24(3), 899-905 · 2024
Structure Determination of Biogenic Crystals Directly from 3D Electron Diffraction Data
A. Wagner, J. Merkelbach, L. Samperisi, N. Pinsk, B. M. Kariuki, C. E. Hughes, K. D. M. Harris, B. A. Palmer
Read the paper →Cryst. Growth Des. 24(14), 5893-5897 · 2024
In the Footsteps of Pasteur: Finding Conglomerates by Using State-of-the-Art Electron Diffraction
I. B. Rietveld, F. Painsecq, C. Jandl, D. Stam, G. Coquerel
Read the paper →CrystEngComm · 2024
Crystal structure of febuxostat marketed polymorph determined by electron diffraction and reinforced by X-ray crystallography
D. T. Ungur, A. Lanza, D. Stam, C. Guguta, C. Iordache, V. Fruth, G. Santiso-Quinones, M. M. Pop
Read the paper →Eur. J. Pharm. Sci. 186, 106447 · 2023
The polymorph landscape of dabigatran etexilate mesylate: taking the challenge to bring a metastable polymorph to market
Sieger, U. Werthmann, S. Saouane
Read the paper →Molbank 2024, M1851 · 2024
Polymorphism of an Nα-Aroyl-N-Aryl-Phenylalanine Amide: an X-ray and electron diffraction study
M. Lang, R. Goddard, M. Patzer, U. S. Ganapathy, T. Dick, A. Richter, R. W. Seidel
Read the paper →Inorg. Chem. 65, 19849 · 2026
Hydration-controlled layer stacking in (NH3)2Cu5(SeO3)2(OH)6·(H2O)2+x (x = 0, 1, 3)
P. R. Baral, C. Jandl, P. Pradal, J. Roos, W. Bi, A. Magrez
Read the paper →Adv. Opt. Mater., e00022 · 2026
3D electron diffraction uncovers the structural origin of delayed dual emission in a heavy-atom-free carbazole hexamer
J. Sivanarayanan, K. Vinod, S. Suresh, A. T., A. Benoy, B. Thomas, M. Hariharan
Read the paper →News Highlights
A few pinned stories worth a look. See all news →
Application · 2026-05-20
How 3D electron diffraction solved lutein – and enabled a landmark patent
A structure determination that underpinned a landmark patent.
Read more →Distribution · 2026-04-16
ELDICO to enable first dedicated MicroED deployment in Asia-Pacific
Crystal Pharmatech brings dedicated electron diffraction to the Asia-Pacific region.
Read more →Insight · 2026-02-27
Electron diffraction: the missing link between SC-XRD and XRPD
Where dedicated electron diffraction fits between single-crystal and powder X-ray.
Read more →The Nano-crystallography Update
New 3D electron-diffraction structures, methods, publications and webinars – a few times a quarter.
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