Case study
Working with micrograms instead of milligrams.
A structure solved from a sub-microgram, impure sample – where there simply wasn't enough material for any conventional method.
The challenge
Less than 1 mg, and not an option for anything else.
A leading pharmaceutical company approached us with an HPLC fraction containing less than 1 mg of an unknown natural product – a honey-like, gel-type substance, clearly not fully pure and difficult to analyse by any other method. The task: obtain structural information from it. Conventional approaches were simply not an option.
What ELDICO did
Precision at the sub-microgram scale.
Drawing on our expertise in micro-filtration and micro-crystallisation, we worked the material down to a single measurable crystallite – and solved it.
< 100 µg crystallised
Crystallised less than 100 µg of sample directly onto a 3 mm TEM grid, ready for measurement.
New compound solved
Determined the structure of a new macro-cyclic natural compound by electron diffraction.
Insight from an impure sample
Delivered structural certainty from a sub-microgram, non-pure fraction – no bulk crystallisation required.
Download the case study if
This sounds like your sample.
- You don't have enough material available.
- You haven't been able to isolate your compound of interest.
- You haven't been able to crystallise your target molecule.
- You haven't been able to structurally characterise your (new) compound.
Download the full case study.
See how we crystallised less than 100 µg and solved a new macro-cyclic natural product by electron diffraction.
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