Avoid tedious crystallisation – save time & money
A crystal with approx. size of 0.6 x 0.3 x 0.1 µm was located and aligned by still images in STEM mode and diffraction data was collected in steps of 0.5° per frame while the crystal was continuously rotated at 1° per second over a range of 120°.
Getting a crystal structure from a pseudo-twinned sample of tyrosine, i.e. two crystals measured at the same time.
One single run spanning an angular range of 100° phi rotation was recorded in 1° steps with an exposure time of 0.5 s per frame.
Determine the absolute configuration of a chiral compound
Diffraction data was collected in steps of 0.5° per frame while the crystal was continuously rotated at 1° per second over a range of 120°.
We are in constant dialogue with research and manufacturing industries in the pharmaceutical, agrochemical and advanced materials sector, as well as contract research organizations and academic research institutes.
”The continued development and application of electron diffraction is particularly important because it enables structural analysis of individual crystals that are too small to be measured by X-ray diffraction.”
”A dedicated device for electron diffraction would open up a lot of new possibilities. I see new possibilities in materials science, I see possibilities in pharmacology, in organic chemistry. I see incredible possibilities in the fields where what is critical is the size of the crystal.”
”In order to solve structures not accessible by X-ray powder diffraction, it was necessary to improve the acquisition of diffraction data significantly. When, in 2007, the first ab-initio structural analysis of barite was performed, I did not yet realize that this would be the foundation for a widely applicable 3D electron diffraction method.”
”Over the past decades, electron diffraction has been a regular tool in our analyses of inorganic materials. ED instruments with proper, more tailored functionalities are required to adequately address the requirements of the crystallographic structure analysis community.”
”There are many diverse applications for electron diffraction in materials science and chemistry. Heterogeneous catalysts need to be very small to enlarge the relative surface. The grains are too small for X-ray crystallography, whereas ED makes it possible to determine their crystal structure at the original size.”
”Determination of the absolute configuration of organic molecules is essential in drug development and the subsequent approval process. This determination is possible thanks to electron diffraction using nanocrystalline material.”